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Institution Faculty of Medicine - Walther Straub Institute of Pharmacology and Toxicology
Remuneration group TV-L
Full-time / Part-time Part-time (100 % for Postdoctoral Researcher; 50 % for PhD Student)
Start date As soon as possible (The position is initially limited til June 2026)
Application deadline 2022-12-09

About us:

The Nicke lab offers a position in the frame of P2X7 Receptor Signaling (associated with CRC 1328 - Adenine Nucleotides in Immunity and Inflammation).
The P2X7 receptor is an ATP-gated ion channel and key mediator of inflammation. Its activation results in a variety of effects (e.g. cytokine secretion, cell morphology changes, apoptosis) that are incompletely understood (Kopp et al. Front. Mol. Neurosci.). In the proposed project we aim to use P2X7 knock-out and BAC transgenic P2X7-EGFP mouse models (Kaczmarek-Hájek, Zhang, Kopp et al., eLife, 2018) in combination with biochemical (cross-linking mass spectrometry), biophysical (two-electrode voltage clamp, voltage clamp fluorometry) and functional approaches (migration assays, fluorescence imaging) to identify and validate identified P2X7 interaction partners and possible roles of P2X7 cell migration.

We are looking for you:

Postdoctoral (100%) and PhD (50%) positions in P2X7 Receptor Signaling (m/f/x)

in Munich

Your tasks and responsibilities:

In the proposed project we aim to use P2X7 knock-out and BAC transgenic P2X7-EGFP mouse models (Kaczmarek-Hájek, Zhang, Kopp et al., eLife, 2018) in combination with biochemical (cross-linking mass spectrometry), biophysical (two-electrode voltage clamp, voltage clamp fluorometry) and functional approaches (migration assays, fluorescence imaging) to identify and validate identified P2X7 interaction partners and possible roles of P2X7 cell migration.

Your qualifications:

  • Outstanding degree (MSc for PhD candidates; PhD for Postdocs) in the area of biomedicine, biochemistry, biology, pharmacy or similar
  • We are looking for highly motivated researchers with enthusiasm for basic science
  • You should have a good background in molecular biology and biochemistry
  • Ability to responsibly plan and perform experiments and to work in an international team
  • Experience in working with genetically modified mice, functional analysis of in channels and cell migration assays is an advantage
  • Postdoctoral researcher: organization and supervision of research projects

Benefits:

We are an interdisciplinary and international group and integrated in several research networks that enable scientific exchange with leading scientists in the field and multiple training possibilities as well as access to state-of-the-art instrumentation and facilities. The institute is located in the middle of Munich and the Bavarian lakes and Alps can be easily reached by public transport in less than 1h.
The position is initially limited til June 2026, with a possibility of extension. Salary is determined by prior experience according to the German public sector pay scale TV-L.

People with disabilities who are equally as qualified as other applicants will receive preferential treatment.

Contact:

Please send your complete application (including a letter of motivation, CV with certificates, and two reference letters) in a single pdf file (not exceeding 10 MB) until 09.12.2022 to
 
LMU Munich
Walther Straub Institute of Pharmacology and Toxicology
Professor Annette Nicke
Nussbaumstr. 26
80336 Munich
Annette.Nicke@lrz.uni-muenchen.de

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